WBA featherweight champion Leo Santa Cruz (32-0-1, 18 KO) will defend his title against the world rated Carl Frampton (22-0, 14 KO) later this summer.
Frampton's manager Barry McGuigan made the announcement on Friday, two months after the IBF bantamweight champion outpointed Scott Quigg to unify the division.
Santa Cruz, 27, won the World Boxing Association title with a majority-decision win over Abner Mares last year, and has defended it once after stopping Kiko Martinez in five rounds.
Talks between the two promotions had commenced a couple of months ago, and after ongoing discussions, New York will host the eagerly anticipated title showdown between two of the division's finest talents.
Both men have won world championships at super-bantamweight - and having faced high quality opposition in Abner Mares, Scott Quigg and Kiko Martinez respectively - is regarded as a closely matched contest.
On the undercard, Frampton's compatriot Andy Lee will also challenge for a world title against WBA middleweight champion Danny Jacobs.
A date is yet to be confirmed.