|Image: Sky Sports|
This is a huge game for Sevilla because a defeat in Manchester will leave them in a precarious position in terms of qualifying from Group D and reaching the knockout stages.
Here, TheSportMatrix's La Liga expert Adam (@AdamLaLiga) breaks down everything Sevilla ahead of the trip to England.
Sevilla can make it out of this group as I've said from day one but what is hampering their progress is their poor start to the season because they haven't reached last season's levels and look weak infront of goal.
Sevilla in Week 7 of La Liga though reached close to last season's levels and it was the best I've seen them play this season against a Barca side who they beat 2-1 on the day and those levels must be shown in Manchester.
Against Juventus though they couldn't offer anything in attack and in the final third they looked out of ideas and lacklustre but against Barca in Week 7 of La Liga they showed better levels and looked like the Sevilla we loved and we know and one that can beat anyone in Europe on their day.
The Sanchez Pizjuan hosts Manchester City and Juventus and it'll play a big part in deciding who clinches the two spots from this group to qualify believe me because there's simply no way an English side wins there.
Sevilla have injuries and aren't at full strength and haven't been this season so it's worth bearing in mind and they have their best two centre-backs Carrico and Pareja out injured with both looking at November and December time until they can return to the side.
For this match Sevilla have doubts over defender Adil Rami, winger Gael Kakuta, goalkeeper Beto, left-back Escudero and the brilliant playmaker that is Ever Banega who is one of the most under-rated attacking midfielders in Europe in my opinion.
Sevilla last season away from home were naive defensively in the respect that they always gave you a chance defensively and very rarely did they keep a clean sheet on their travels but so far this season they've shown themselves to be well organised and harder to have a chance against defensively.
You have to work to create chances against this Sevilla side this season but when you take out the Barca game in Week 7 they haven't looked themselves in the final third but the Barca result in my opinion is just the tonic Sevilla needed and it will kickstart their season.
Coach Unai Emery has said that Sevilla need to find solutions and they certainly found them against Barca and although he still doesn't know his best eleven, it's worth taking into account the key players missing through injury which isn't helping Sevilla at all.
Sevilla remind me of Athletic Bilbao in the Champions League last season where they are in a group which they are better than Manchester City and Borussia Monchengladbach but their poor start to the season and lack of form sees them in trouble.
Athletic Bilbao picked up form and starting looking like they were the second best side in their group last season but it was too late and they narrowly missed out on securing second place and were eliminated and ended up in the UEFA Europa League.
I really really hope we don't see that happen again this season with Sevilla but if there is a saving grace for Sevilla it's the fact that there is an English club in their group because English clubs are years behind La Liga sides.
Emery doesn't know his best eleven yet so it's hard to predict what the eleven that take to the field in Manchester on Tuesday night will be but for me he needs to pick an eleven as close as he can to the one that beat Barca.
N'Zonzi cannot start though because even though this is against an English side who's played alot against in recent seasons he really does need to improve, his decision making and his clumsy tackles are costing Sevilla when they are defending by the fact he is giving away needless set pieces in very dangerous positions!
This would be my eleven that takes to the field in Manchester on Tuesday night, if Banega is fit then he would replace Krohn-Delhi in my eleven which is below...
As a follower and lover of Spanish Football it doesn't take long to work out that I want La Liga sides to do well in Europe and that includes this game and I really am hoping Sevilla win this because it would be massive and decisive in this group!
The defending in England is extremely poor and the Etihad Stadium in Manchester is a big pitch which will suit Sevilla and on the counter-attack they can damage an average European outfit here and I think this game will be won on the counter-attack and won by the Andalusians.